Neurochemical and electrophysiological deficits in the ventral hippocampus and selective behavioral alterations caused by high-fat diet in female C57BL/6 mice.
Neuroscience(2015)
摘要
•Five weeks of high-fat diet (HFD) intake increases anxiety in female C57BL/6 mice.•Short-term object recognition memory is intact after 5weeks of HFD intake.•Six-week HFD intake alters prefrontocortical/ventral hippocampal (vHIP) monoamines.•Eleven to twelve weeks of HFD consumption reduces synaptic plasticity in the vHIP.•Overall, HFD intake alters specific behaviors and linked monoamines in female mice.
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关键词
3-MT,5-HIAA,5-HT,aCSF,ANOVA,DA,dHIP,DOPAC,EPM,fEPSPs,FST,HFD,HFS,HVA,LFD,LTP,MBT,MHPG,N,NAc,NE,NPIs,NOR,PFC,PPR,vHIP
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