[Correlation of insulin-like growth factor 1 expression in placenta with DNA methylation and fetal macrosomia].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics(2015)
Abstract
No linear correlation was found between placental IGF-1 expression and methylation level of IGF-1 promoter with a hypomethylation status. The contribution of placental IGF-1 expression to birth weight is bidirectional. Increased expression seems to promote fetal growth, while decreased expressions may curb overgrowth, therefore control fetal growth in a relatively normal range.
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Key words
Macrosomia,Placenta,IGF-1 gene,DNA methylation
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