Discovery Of Novel Cyanamide-Based Inhibitors Of Cathepsin C
ACS MEDICINAL CHEMISTRY LETTERS(2011)
摘要
The discovery of potent and selective cyanamide-based inhibitors of the cysteine protease cathepsin C is detailed. Optimization of the template with regard to plasma stability led to the identification of compound 17, a potent cathepsin C inhibitor with excellent selectivity over other cathepsins and potent in vivo activity in a cigarette smoke mouse model.
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关键词
Cathepsin C inhibitors,cyanamides,potent,selective,cigarette smoke
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