Revealing the cerebral regions and networks mediating vulnerability to depression: oxidative metabolism mapping of rat brain.

•Findings on neurobiology of depression in different animal models are hard to compare.•We analyzed data on brain oxidative metabolism across five rat models of depression.•Brain areas universally involved in stress response and vulnerability were revealed.•Diathesis-stress approach suggests brain regions mediating adaptation to stress.•Connectivity patterns in conditions of resilience and vulnerability are distinct.