PG201 downregulates the production of nitrite by upregulating heme oxygenase-1 expression through the control of phosphatidylinositol 3-kinase and NF-E2-related factor 2.

Jinyong Choi,Junsub Lee,Junghun Lee,Seon-Hee Kim,Jiyoung Kim,Sunyoung Kim

Nitric Oxide（2013）

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摘要

•PG201 enhanced the level of HO-1 expression through the StRE in its promoter.•PG201 increased both the total and nuclear levels of Nrf2.•PG201 activated Nrf2 and HO-1 through the PI3K signal transduction pathway.•PG201 inhibited the expression of iNOS, thus lowering the production of nitrite.

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关键词

PG201,Heme oxygenase-1,Nrf2,Phosphatidylinositol 3-kinase,Nitrite,Inducible nitric oxide synthase

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