Dibenzotetraaza[14]Annulene-Adenine Conjugate Recognizes Complementary Poly Dt among Ss-Dna/Ss-Rna Sequences
ORGANIC & BIOMOLECULAR CHEMISTRY(2013)
摘要
Among three novel DBTAA derivatives only the DBTAA-propyl-adenine conjugate showed recognition of the consecutive oligo dT sequence by increased affinity and specific induced chirooptical response in comparison to other single stranded RNA and DNA; whereby of particular importance is the up until now unique efficient differentiation between dT and rU. At variance, its close analogue DBTAA-hexyl-adenine did not reveal any selectivity between ss-DNA/RNA pointing out the important role of steric factors (linker length); moreover non-selectivity of the reference compound (, lacking adenine) stressed the importance of adenine interactions in the selectivity.
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关键词
DNA nanotechnology
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