Inhibition of DNA Topoisomerases I and II and Cytotoxicity by Lignans from Saururus Chinensis.
Archives of pharmacal research(2009)
摘要
Thirteen lignans, erythro -austrobailignan-6 ( 1 ), meso -dihydroguaiaretic acid ( 2 ), sauchinone ( 3 ), 1′- epi -sauchinone ( 4 ), saucerneol D ( 5 ), manassantin B ( 6 ), manassantin A ( 7 ), nectandrin B ( 8 ), machilin D ( 9 ), saucerneol F ( 10 ), saucerneol G ( 11 ), saucerneol H ( 12 ) and saucerneol I ( 13 ), were isolated from the ethyl acetate extract of the roots of Saururus chinensis . Among these compounds, 5 showed potent inhibitory activities against DNA topoisomerase I and II, and 5, 6, 7 and 10 showed mild cytotoxicities against HT-29 (IC 50 values; 13, 12, 11, and 10 µM, respectively) and HepG2 cell lines (IC 50 values; 16, 11, 12, and 11 µM, respectively).
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关键词
Saururus chinensis,Saururaceae,Lignan,Topoisomerase,Cytotoxicity
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