Clinical Aspect of Recent Progress in Phosphate Metabolism. Bone As an Endocrine Organ

FGF23, secreted by bone, inhibits renal phosphate reabsorption. Recently, it was reported that osteocalcin, secreted by bone, promotes adiponectin and insulin secretion and improves glucose metabolism. Thus, bone does not just work for a storage of calcium or resisting against gravity but an endocrine organ to affect other tissues.