Probing the Lactose.gm3 Carbohydrate-Carbohydrate Interaction with Glycodendrimers.

Nicole Seah,Paul V. Santacroce,Amit Basu

Organic Letters（2009）

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摘要

Multivalent glycoconjugates were prepared using generation-4 PAMAM dendrimers, and their interaction with Langmuir monolayers containing GM3 was investigated. Excessive carbohydrate valency adversely affects the carbohydrate-carbohydrate interaction. The GM3 monolayer selectively interacts with lactose-functionalized dendrimers in the presence of calcium ions.

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Carbohydrate-Based Drug Design

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