Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β
Nature(2012)
摘要
It is shown that the formation of amyloid-β oligomers, one of the histopathological signatures of Alzheimer’s disease, can be triggered by small quantities of a specifically truncated and post-translationally modified version of amyloid-β.
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关键词
Alzheimer's disease,Neuronal physiology,Prions,Structural biology,Science,Humanities and Social Sciences,multidisciplinary
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