Meta-analyses Identify 13 Loci Associated with Age at Menopause and Highlight DNA Repair and Immune Pathways.

Lisette Stolk,John R B Perry,Daniel I Chasman,Chunyan He,Massimo Mangino,Patrick Sulem,Maja Barbalic,Linda Broer,Enda M Byrne,Florian Ernst,Tõnu Esko,Nora Franceschini,Daniel F Gudbjartsson,Jouke-Jan Hottenga,Peter Kraft,Patrick F McArdle,Eleonora Porcu,So-Youn Shin,Albert V Smith,Sophie van Wingerden,Guangju Zhai,Wei V Zhuang,Eva Albrecht,Behrooz Z Alizadeh,Thor Aspelund,Stefania Bandinelli,Lovorka Barac Lauc,Jacques S Beckmann,Mladen Boban,Eric Boerwinkle,Frank J Broekmans,Andrea Burri,Harry Campbell,Stephen J Chanock,Constance Chen,Marilyn C Cornelis,Tanguy Corre,Andrea D Coviello,Pio d'Adamo,Gail Davies,Ulf de Faire,Eco J C de Geus,Ian J Deary,George V Z Dedoussis,Panagiotis Deloukas,Shah Ebrahim,Gudny Eiriksdottir,Valur Emilsson,Johan G Eriksson,Bart C J M Fauser,Liana Ferreli,Luigi Ferrucci,Krista Fischer,Aaron R Folsom,Melissa E Garcia,Paolo Gasparini,Christian Gieger, Nicole Glazer,Diederick E Grobbee,Per Hall,Toomas Haller,Susan E Hankinson,Merli Hass,Caroline Hayward,Andrew C Heath,Albert Hofman,Erik Ingelsson,A Cecile J W Janssens,Andrew D Johnson,David Karasik,Sharon L R Kardia,Jules Keyzer,Douglas P Kiel,Ivana Kolcic,Zoltán Kutalik,Jari Lahti,Sandra Lai,Triin Laisk,Joop S E Laven,Debbie A Lawlor,Jianjun Liu,Lorna M Lopez,Yvonne V Louwers,Patrik K E Magnusson,Mara Marongiu,Nicholas G Martin,Irena Martinovic Klaric,Corrado Masciullo,Barbara McKnight,Sarah E Medland,David Melzer,Vincent Mooser,Pau Navarro,Anne B Newman,Dale R Nyholt,N Charlotte Onland-Moret,Aarno Palotie,Guillaume Paré,Alex N Parker,Nancy L Pedersen,Petra H M Peeters,Giorgio Pistis,Andrew S Plump,Ozren Polasek,Victor J M Pop,Bruce M Psaty,Katri Räikkönen,Emil Rehnberg,Jerome I Rotter,Igor Rudan,Cinzia Sala,Andres Salumets,Angelo Scuteri,Andrew Singleton,Jennifer A Smith,Harold Snieder,Nicole Soranzo,Simon N Stacey,John M Starr,Maria G Stathopoulou,Kathleen Stirrups,Ronald P Stolk,Unnur Styrkarsdottir,Yan V Sun,Albert Tenesa,Barbara Thorand,Daniela Toniolo,Laufey Tryggvadottir,Kim Tsui,Sheila Ulivi,Rob M van Dam,Yvonne T van der Schouw,Carla H van Gils, Peter van Nierop,Jacqueline M Vink,Peter M Visscher,Marlies Voorhuis,Gérard Waeber,Henri Wallaschofski,H Erich Wichmann,Elisabeth Widen,Colette J M Wijnands-van Gent,Gonneke Willemsen,James F Wilson,Bruce H R Wolffenbuttel,Alan F Wright,Laura M Yerges-Armstrong,Tatijana Zemunik,Lina Zgaga,M Carola Zillikens,Marek Zygmunt, The LifeLines Cohort Study,Alice M Arnold,Dorret I Boomsma,Julie E Buring,Laura Crisponi,Ellen W Demerath,Vilmundur Gudnason,Tamara B Harris,Frank B Hu,David J Hunter,Lenore J Launer,Andres Metspalu,Grant W Montgomery,Ben A Oostra,Paul M Ridker,Serena Sanna,David Schlessinger,Tim D Spector,Kari Stefansson,Elizabeth A Streeten,Unnur Thorsteinsdottir,Manuela Uda,André G Uitterlinden,Cornelia M van Duijn,Henry Völzke,Anna Murray,Joanne M Murabito,Jenny A Visser,Kathryn L Lunetta

Nature Genetics（2012）

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摘要

Kathryn Lunetta and colleagues report a meta-analysis of 22 genome-wide association studies for age at menopause. They identify 13 loci newly associated with age at natural menopause, including several candidate genes with roles in DNA repair and immune function.

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