Home Blood Pressure Monitoring In Addition To Office Blood Pressure Is Useful In Patients With Systolic Hypertension Before Their Inclusion Into A Drug Trial
ARCHIVES DES MALADIES DU COEUR ET DES VAISSEAUX(2006)
摘要
Objective: in patients with uncontrolled systolic hypertension, to estimate the value of home blood pressure monitoring in addition to office blood pressure for inclusion in a trial.Methods: 80 patients with systolic hypertension, defined as SBP >= 140 mmHg and pulse pressure >= 60 mmHg, were treated for 4 weeks with a thiazide diuretic at usual dose (25 mg HCTZ or 1.5 mg indapamide or methyclothiazide 5 mg). Blood pressure was measured using an automatic monitor (Omron M6) at office and at home in the 3 days prior the visit. Subjects with an uncontrolled hypertension were included in the second part of the trial only if there fulfilled inclusion criteria: office SBP 140 mmHg and home SBP >= 135 mmHg (mean of 18 measurements obtained on 3 consecutive days) and office pulse pressure >= 60 mmHg.Results: after 4 weeks with diuretic treatment, 62% of patients fulfilled 3 criteria and were included in the second part of the trial. It was observed 76% of patients with office SBP >= 140 mmHg, 72% with office pulse pressure >= 60 mmHg and 70% with both office SBP and PP criteria. However, only 67% of patients had home SBP >= 135 mmHg. Discrepancy between office and home SBP was observed and subjects with a white coat hypertension was noticed in 14% and masked hypertension in 5%.Conclusion: if patients with systolic hypertension have to be included into a drug trial because there are uncontrolled, home blood pressure monitoring in addition to office blood pressure is a very useful criteria for inclusion because misclassifications due to white coat or masked hypertension is frequent in these patients.
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关键词
home blood pressure monitoring,office blood pressure determination,systolic hypertension,drug trial
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