Dose-dependent Binding of AZD3783 to Brain 5-HT1B Receptors in Non-Human Primates and Human Subjects: a Positron Emission Tomography Study with [11C]AZ10419369.

The serotonin 5-HT1B receptor is a potential target for the pharmacologic treatment of depression. Positron emission tomography (PET) determination of 5-HT1B receptor occupancy with drug candidates targeting this receptor in non-human primate and human subjects may facilitate translation of research from animal models and guide dose selection for clinical studies. AZD3783 is a recently developed, orally bioavailable 5-HT1B receptor antagonist with potential antidepressant properties.