Increased and Prolonged Lh-Rh/Fsh-Rh Activity of Synthetic (D-Ala6, Des-Gly-Nh210)-Lh-Rh-Ethylamide in Normal Women

A synthetic LH-RH analogue (D-Ala6, Des-Gly-NH210)-LH-RH ethylamide exhibited an increased and prolonged LH-RH/FSH-RH activity in normal women. The integrated amounts of LH and FSH levels for this LH-RH analogue were about nine and five times greater than for the same doses of synthetic LH-RH. It is expected that this synthetic LH-RH analogue might yield more positive results than with LH-RH when used in infertility problems.