Invasin Of Yersinia Pseudotuberculosis Activates Human Peripheral B Cells
INFECTION AND IMMUNITY(1996)
摘要
The Yersinia pseudotuberculosis cell surface-located protein invasin was found to promote binding between the pathogen and resting peripheral B cells via beta(1) integrin receptors (CD29). B cells responded by expressing several activation markers and by growing. In contrast, T cells did not react, although these cells express CD29. An isogenic invA mutant failed to activate B cells. The mutation could be complemented by providing the invA(+) gene in trans. Purified invasin alone did not activate B cells, although it was able to block the binding of bacteria to the cells.
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关键词
yersinia pseudotuberculosis
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