Severe toxicity following induction chemotherapy for acute myelogenous leukemia in a patient with Werner's syndrome.
LEUKEMIA & LYMPHOMA(2009)
摘要
Werner's syndrome is an autosomal recessive disorder resulting in premature aging. Most patients die in their fifth decade from malignancies or heart disease. The gene for Werner's syndrome ( WRN) encodes a recQ helicase. Cells from patients with Werner's syndrome have increased sensitivity to DNA-damaging drugs in vitro. Here we present a patient with Werner's syndrome who developed severe chemotherapy-induced toxicity during treatment for acute myelogenous leukemia. We propose that lack of WRN resulted in increased sensitivity of the patient's cells to the toxicity of chemotherapy.
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关键词
Werner's syndrome,leukemia,chemotherapy,toxicity
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