Effects of Ulinastatin and 1,6 fructose diphosphate on GSH-Px and MDA in cerebral ischemia-reperfusion injury

Objective: To investigate the protective effects of Ulinastatin (UTI) and 1, 6 fructose diphosphate (FDP) on cerebral ischemia-reperfusion injury, and to discuss the protective mechanisms of UTI and FDP on cerebral ischemia-reperfusion injury. Method: Rabbit ischemia-reperfusion injury models were prepared by "four arteries occlusion". All rabbits were divided into four groups (n = 6): control group, UTI (10 U/kg) group, FDP (200 mg/kg) group, UTI + FDP group. Salt water, UTI, FDP and UTI + FDP were respectively used immediately after ischemia-reperfusion. Plasmic MDA and GSH-Px were measured at 30 minutes, 1 hour, 3 hours and 6 hours after reperfusion. Results: The concentrations of plasmic MDA in every group were significantly improved compared with those in control group (P < 0.05) there was significant difference on the concentrations of MDA and GSH-Px between UTI group and UTI + FDP group (P < 0.01). the concentrations of MDA and GSH-Px after 30 minutes had no significant difference between FDP group and UTI + FDP group (P > 0.05), but significant difference could be found after 3 hours (P < 0.01). Conclusions: UTI and FDP have protective effect on cerebral ischemia reperfusion injury. UTI combined with FDP has a significantly better effect than using alone.