Detailed Allelic Loss Mapping on 7q32 in Nasopharyngeal Carcinoma

OBJECTIVE:The present research group had found high frequency of loss of heterozygosity(LOH) of D7S500-D7S495 on chromosome band 7q32 in nasopharyngeal carcinoma, this study was conducted to further find the deletion region.METHODS:Higher density of loci on 7q32 in 30 tumors was studied by using microsatellite analysis.RESULTS:The frequency of LOH was 63.3%. The highest frequency of LOH was identified at the loci of D7S500-D7S509-D7S495, among which a common deletion of D7S509 was found.CONCLUSION:A putative tumor suppressor gene may be present around D7S509.