骨内注射无水乙醇建立兔股骨头坏死模型****☆
Chinese Journal of Tissue Engineering Research(2013)
Abstract
背景:目前还难以建立合适的早期股骨头坏死的动物模型.目的:建立一个简单、标准和可靠的股骨头坏死动物模型用于实验研究.方法:X射线透视下将新西兰兔右侧股骨头中心钻孔并注入无水乙醇,左侧不做处理做对照.经过2,4和6周麻醉下处死动物获取股骨头.结果与结论:大体及X射线观察显示,造模侧股骨头第2周关节软骨颜色变暗、骨质密度不均匀;第6周,关节面有轻微凹陷,骨质低密度影较前进一步增大.MRI显示,造模侧股骨头第2周,T1加权股骨头负重区显示线样或不规则低信号,T2加权呈高信号;第6周,股骨头变性,软骨下骨折,关节面塌陷,新月体形成.对照侧第2,4,6周股骨头结果均常.组织病理学观察显示,造模侧股骨头第2周后,骨细胞核固缩、变性坏死.结果证实,2周后兔股骨头均发生了部分坏死,股骨头坏死的完整的外观形态,大体循环和关节软骨与人类早期股骨头坏死是相似的,提示实验建立了良好的股骨头坏死动物模型.
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Key words
Animal models,Bone tissue construction,Ethanol,Femoral head necrosis,MRI,National natural science foundation of china,Rabbits,Tissue construction,Tissue construction photographs-containing paper,X-ray
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