Surgical Treatment of Hydrosalpinx Improves the Expressions of Integrin Alpha V Beta 3 and L-Selectin Ligand in the Endometrium in Implantation Window

Clinical importance of the improved expressions of integrin alpha v beta 3 and L-selectin ligand in the endometrium following the surgical treatment for hydrosalpinx has been studied. A total of 60 patients with hydrosalpinx and 30 patients with fallopian tube obstruction were recruited. In the implantation window, immnohistochemistry was carried out to detect the expressions of integrin alpha v beta 3 and L-selectin ligand in the endometrium of the hydrosalpinx patients before and after surgery and of patients with fallopian tube obstruction. In the implantation window, the expressions of integrin alpha v beta 3 and L-selectin ligand in the endometrium of hydrosalpinx patients before surgery were significantly lower than those in patients with fallopian tube obstruction (P<0.05). However, there were no marked differences in the expressions of integrin alpha v beta 3 and L-selectin ligand in the implantation window between hydrosalpinx patients after surgical intervention and fallopian tube obstruction patients (P>0.05). Furthermore, for patients with hydrosalpinx, the expressions of integrin alpha v beta 3 and L-selectin ligand in the implantation window were dramatically increased after surgery (P<0.05). Hydrosalpinx decreases the expressions of integrin alpha v beta 3 and L-selectin ligand in the endometrium in implantation window, and integrin alpha v beta 3 and L-selectin ligand may be important factors influencing the endometrial receptivity of hydrosalpinx patients. Surgical treatment for hydrosalpinx can improve the expressions of integrin alpha v beta 3 and L-selectin ligand in the endometrium in implantation window.