Validation of a chiral HPLC assay for (R)-salbutamol sulfate.
Journal of Pharmaceutical and Biomedical Analysis(2004)
Abstract
A fast, reliable and specific method for the screening, confirmation, determination and quantitation of salbutamol enantiomers was developed and validated. The described procedure includes a single robust chiral HPLC determination employing a Teicoplanin stationary phase. The method was evaluated for specificity, robustness, linearity, precision and accuracy. Under the chromatographic conditions of the method, known impurities were separated from the active principle.
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Key words
Albuterol,Salbutamol,HPLC validation,Chiral chromatography,Levalbuterol
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