CLC-7: a potential therapeutic target for the treatment of osteoporosis and neurodegeneration.
Biochemical and Biophysical Research Communications（2009）
Abstract
CLC-7 is a member of the voltage-gated chloride channels family. It resides mainly in the late endosomes, lysosomes and the ruffled membrane of osteoclasts. Mice deficient in the ubiquitously expressed ClC-7 Cl− channel show severe osteopetrosis and retinal degeneration. In the present review, some of the known features of CLC-7 such as structure, function and its roles in physiological or pathophysiological processes are highlighted.
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Key words
CLC-7,Osteoclasts,Endosomes,Lysosomes
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