Effect and side effects of treating chronic myeloid leukemia (CML) by imatinib in pediatric patients
KLINISCHE PADIATRIE(2010)
摘要
Background: Inhibition of the leukemia-specific bcr-abl gene rearrangement by the tyrosine kinase inhibitor (TKI) imatinib mesylate (IMA) has dramatically improved therapy of chronic myeloid leukemia (CML). Study CML-paed-II is active within the GPOH and I-BFM networks recommending IMA as frontline treatment for children since 2007. However, pediatric experience is still limited and besides bcr-abl IMA also inhibits other TKs involved in cell signal transduction of bone metabolism. So far, it is regarded upon as to non-specifically inhibit a) the development of osteoblasts from mesenchymal stem cells b) the activity of mature osteoblasts and c) the differentiation of osteoclasts from monocytes by non selectively inhibiting type-III TKs like c-kit, FLT3, PDGFR, and c-fms.
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关键词
chronic myeloid leukemia,imatinib,side effects
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