Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

Gijs van Haaften,Gillian L Dalgliesh,Helen Davies,Lina Chen,Graham Bignell,Chris Greenman,Sarah Edkins,Claire Hardy,Sarah O'Meara,Jon Teague,Adam Butler,Jonathan Hinton,Calli Latimer,Jenny Andrews,Syd Barthorpe,Dave Beare,Gemma Buck,Peter J Campbell,Jennifer Cole,Simon Forbes,Mingming Jia,David Jones,Chai Yin Kok,Catherine Leroy,Meng-Lay Lin,David J McBride,Mark Maddison, Simon Maquire,Kirsten McLay,Andrew Menzies,Tatiana Mironenko,Lee Mulderrig,Laura Mudie,Erin Pleasance,Rebecca Shepherd,Raffaella Smith,Lucy Stebbings,Philip Stephens,Gurpreet Tang,Patrick S Tarpey,Rachel Turner,Kelly Turrell,Jennifer Varian,Sofie West,Sara Widaa,Paul Wray,V Peter Collins,Koichi Ichimura,Simon Law,John Wong,Siu Tsan Yuen,Suet Yi Leung,Giovanni Tonon,Ronald A DePinho,Yu-Tzu Tai,Kenneth C Anderson,Richard J Kahnoski,Aaron Massie,Sok Kean Khoo, Bin Tean Teh, Michael R Stratton,P Andrew Futreal

Nature Genetics（2009）

引用 741|浏览162

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摘要

ndrew Futreal and colleagues report inactivating somatic mutations in the histone lysine demethylase gene UTX in human cancers, including multiple myelomas, esophageal squamous carcinomas, renal clear cell carcinomas, acute and chronic myeloid leukemias, breast and colorectal cancers and glioblastomas, identifying UTX as a new tumor suppressor gene.

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Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics

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