The coatomer of Trypanosoma brucei

Coatomer is a multisubunit complex involved in trafficking of vesicles between the endoplasmatic reticulum and the Golgi apparatus. From sequence homologies, all seven subunits, α-, β-, β′-, γ-, δ-, ε-, and ζ-COP, are encoded in the genome of Trypanosoma brucei. The complete predicted amino-acid sequences of β-, β′-, and ζ-COP show only 20–30% identity with higher eucaryotic homologues. The trypanosome coatomer complex was partially purified using a procedure similar to that used for bovine coatomer.