加味补中益气汤治疗慢性阻塞性肺疾病稳定期临床研究
Liaoning Journal of Traditional Chinese Medicine(2009)
Abstract
目的:研究加味补中益气汤对COPD稳定期患者的临床疗效及对肺功能、血气分析和血中PDGF-BB的影响。方法:60例COPD稳定期患者随机分为两组,西医对照组予口服茶碱缓释片治疗,中医组以口服加味补中益气汤进行治疗,两组疗程均为14天。观察临床疗效,测定治疗前后FEV1/预计值%、FEV1/FVC%,PaO2、PaCO2、血中PDGF-BB浓度。结果:中医组总有效率93.3%,高于西医对照组(70.0%)(P<0.05);治疗后FEV1/预计值%,FEV1/FVC%,PaO2,PaCO2等指标均较治疗前显著改善(P<0.05),与西医对照组治疗后比较有显著性差异(P<0.05);两组血中PDGF-BB浓度均高于健康对照组(P<0.001),中医组治疗后血中PDGF-BB含量明显下降,与西医对照组比较有显著性差异(P<0.001)。结论:加味补中益气汤能有效改善COPD稳定期患者临床症状体征、肺通气功能、血气指标,降低血中PDGF-BB浓度,抑制气道重塑。
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Key words
Platelet-derived growth factor,the therapeutics of reinforcing qi and promoting blood flow and dissipating phlegm,Chronic Obstructive Pulmonary Disease,airway remodeling,Jiawei buzhong yiqi Recipe
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