Induction of Myasthenia Gravis in HLA Transgenic Mice by Immunization with Human Acetylcholine Receptors.
Annals of the New York Academy of Sciences(2003)
摘要
Abstract: We utilized HLA transgenic mice to identify the dominant epitopes on the human (H)‐AChR α subunit. The cytoplasmic H‐AChR peptide α320–337 was the dominant T cell epitope for DQ8, DR3, and DQ8×DQ6 F1 mice. The H‐AChR‐immunized HLA‐DQ8, DR3, DQ8×DR3 F1 and DQ8×DQ6 F1 mice developed clinical EAMG, whereas HLA‐DQ6 mice were less susceptible.
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关键词
myasthenia gravis (MG),experimental autoimmune myasthenia gravis (EAMG),AChR,HLA transgenic mice
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