可溶性主要组织相容性复合体Ⅰ类链相关蛋白A表达水平与妇科恶性肿瘤的相关性
Chinese Journal of Biologicals(2011)
Abstract
目的分析血清中可溶性主要组织相容性复合体Ⅰ类链相关蛋白A(Soluble major histocompatibility complexclass I chain-related protein A,sMICA)与妇科恶性肿瘤的相关性。方法应用ELISA法检测59例确诊为妇科恶性肿瘤患者和98名健康对照者血清中sMICA的水平,应用ROC曲线对检测结果进行分析与评价。结果病例组患者血清中sMICA平均水平[(1.04±1.33)ng/ml]明显高于健康对照组[(0.29±0.30)ng/ml)],且差异有统计学意义(P<0.000 1)。ROC曲线下面积为0.816,sMICA的临床诊断界点为0.302 ng/ml。结论血清中sMICA水平与妇科恶性肿瘤的发生密切相关,有望作为临床妇科肿瘤诊断的一种新型肿瘤标志物。
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Key words
Genital tumor,Diagnosis,female,ROC curve,Major histocompatibility complex,Soluble MICA
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