类风湿关节炎患者抗环瓜氨酸肽、角质蛋白抗体和类风湿因子相关性探讨
China Practical Medicine(2010)
Abstract
目的 对类风湿性关节炎患者血清抗环瓜氨酸肽(CCP)、角质蛋白抗体(AKA)和类风湿因子(RF)进行检测,并对这些抗体间相关性进行探讨.方法 采用酶免疫法检测抗环瓜氨酸肽抗体;间接免疫荧光法(IIF)检测AKA;采用乳胶凝集法检测RF;采用卡方检验对结果进行统计学比较.结果 RA患者血清中抗CCP阳性率83.3%(75/90),AKA(1:10)阳性率44.4%(40/90),RF(1:20)阳性率66.7%(60/90).结论 虽然RA患者血清中可出现上述三种抗体,但AKA与抗CCP、AKA与RF之间无相关性,而抗CCP与RF之间有相关性.
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Key words
Rheumatoid arthritis,Antikeratin antibody,Rheumatoid factor,Cyclic citrullinated peptid
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