Anthranilamide inhibitors of factor Xa.
Bioorganic & medicinal chemistry letters（2007）
摘要
SAR about the B-ring of a series of N(2)-aroyl anthranilamide factor Xa (fXa) inhibitors is described. B-ring o-aminoalkylether and B-ring p-amine probes of the S1' and S4 sites, respectively, afforded picomolar fXa inhibitors that performed well in in vitro anticoagulation assays.
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关键词
protease inhibitor,factor Xa,anticoagulant
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