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DNA修复酶和拓朴异构酶Ⅱα在乳腺癌中的表达及临床意义

王金科,张辉,董建峰, 赵秋振, 薄爱华

JOURNAL OF HEBEI NORTH UNIVERSITY(MEDICAL EDITION)（2006）

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Abstract
目的:探讨乳腺癌中拓朴异构酶Ⅱα(TopoⅡα)和DNA修复酶(MGMT)表达的相关性及临床意义.方法:采用SABC免疫组织化学方法,检测76例乳腺癌标本中TopoⅡα和MGMT的表达率.结果:乳腺癌中MGMT阳性率为59.21%(45/76),TopoⅡα阳性率为68.42%(52/76).TopoⅡα和MGMT有低度相关性(γ=0.234),61岁以上老年组TopoⅡα和MGMT阳性率均低于60岁以下组,有淋巴结转移组阳性率高于无转移组.结论:TopoⅡα和MGMT过表达率与乳癌患者年龄及有否淋巴结癌转移有关.检测乳腺癌中TopoⅡα和MGMT对提示预后和临床选择化学治疗方案有指导意义.
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