3-Cyano-6-(5-methyl-3-pyrazoloamino)pyridines: Selective Aurora A kinase inhibitors

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

Compound 6 exhibited a potent Aurora A kinase inhibitory activity (Ki=1.2nM) and was effective in antitumor mice model at a dose of 30mg/kg po qd.

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关键词

Aurora kinase,Cyanopyridine,Aminopyrazole

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