3-Cyano-6-(5-methyl-3-pyrazoloamino)pyridines: Selective Aurora A kinase inhibitors
Bioorganic & Medicinal Chemistry Letters(2010)
摘要
Compound 6 exhibited a potent Aurora A kinase inhibitory activity (Ki=1.2nM) and was effective in antitumor mice model at a dose of 30mg/kg po qd.
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关键词
Aurora kinase,Cyanopyridine,Aminopyrazole
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