Fluorinated non-imidazole histamine H3 receptor antagonists.

K Isensee,M Amon,A Garlapati, A Galaparti,X Ligneau,J-C Camelin,M Capet,J-C Schwartz,H Stark

Bioorganic & Medicinal Chemistry Letters（2009）

引用 31|浏览8

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摘要

Novel dibasic fluorinated non-imidazole histamine H3 receptor antagonists were prepared with high affinities at hH3 receptor in the nanomolar and subnanomolar concentration range and some with high antagonist in vivo potencies.

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关键词

Histamine,H3,Receptor,GPCR,Medicinal chemistry,PET,CNS,Neurotransmitter

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