Polyfluorinated bipyridine cisplatins manipulate cytotoxicity through the induction of S-G2/M arrest and partial intercalation mechanism.

In the electrophoretogram the complex 4 (or cisplatin)-treated pSECTag 2/Hygro B plasmid DNA, significant comigration of open circular form and covalent closed circular form was observed and a coalescence of two main bands was found subsequently at low concentrations. A strong unwinding of negative supercoiled DNA to positive supercoiled DNA was detected at high concentrations of cisplatin, whereas the same binding mode with complex 4 was not observed.