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A one-pot synthesis of trichloromethylated pyrimidines from trichloroacetimidamides and acetylenic esters

Issa Yavari,Alaleh Malekafzali,Reza Eivazzadehkeihan,Stavroula Skoulika,Rahman Alivaisi

Tetrahedron Letters（2016）

Cited 10|Views4
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Abstract
A one-pot synthesis of functionalized trichloromethylated pyrimidines from the reaction of trichloroacetimidamides, generated by the addition of guanidine derivatives to trichloroacetonitrile, and acetylenic esters, in good yields is described.
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Key words
Pyrimidine,Trichloroacetonitrile,Tetramethylguanidine,Acetylenic ester
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