恩度联合化疗治疗晚期消化道癌的安全性观察
Journal of Basic and Clinical Oncology(2008)
Abstract
目的评价恩度联合化疗用于治疗晚期食管癌、胃癌、大肠癌的安全性。方法晚期食管癌1例,晚期胃癌4例,晚期肠癌2例,给予恩度10 mg/m2,静脉滴注d1-14,联合紫杉醇/草酸铂/5-Fu,CPT-11/5-Fu,FOLFOX4或FOLFIR I等方案,给药后监测毒副反应。结果7例主要毒副反应表现为Ⅰ~Ⅱ度骨髓抑制、转氨酶升高,均为可逆性,无严重治疗相关毒副反应。结论恩度联合化疗用于治疗晚期消化道癌毒副反应可耐受,安全性良好,值得进一步观察疗效。
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Key words
esophageal/gastric and colorectal cancer,chemotherapy,endostar
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