胃癌中血小板衍生内皮细胞生长因子的表达与微血管生成
Chinese Archives of General Surgery(Electronic Version)(2008)
Abstract
目的研究探讨胃癌组织中血小板衍生内皮细胞生长因子(PD-ECGF)的表达及微血管密度(MVD)与胃癌生物学行为和血管生成的关系。方法应用免疫组化ElivisionTM法检测52份胃癌组织中PD-ECGF、CD34的表达并测定MVD,回顾分析胃癌患者的临床病理资料。结果胃癌组织中PD-ECGF的表达率为59.62%,平均MVD为72.60±16.87;伴有淋巴结转移组、侵及浆膜或浆膜外组的PD-ECGF的阳性率及MVD显著高于无淋巴结转移组、浸润深度未达浆膜层组,且Ⅲ期和Ⅳ期组的MVD高于Ⅰ期和Ⅱ期组;PD-ECGF阳性组的MVD高于阴性组。结论PD-ECGF参与了胃癌的浸润和转移及血管生成,PD-ECGF作为肿瘤抗血管治疗的靶点具有一定的价值。
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Key words
PD-ECGF,Angiogenesis,Microvascular Density,Gastric carcinoma
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