Synthesis and some properties of 2-amino-4-aryl-6-hexyl7-hydroxy-4<i>h</i>-chromene-3-carbonitriles
Журнал общей химии(2023)
摘要
Three-component condensation of aromatic aldehydes with malononitrile and 4-hexylresorcinol in toluene in the presence of a base leads to the formation of 2-amino-4-aryl-6-hexyl-7-hydroxy-4 H -chromene-3-carbonitriles in good yields (79-90%). Structure of the compounds was studied using the methods of two-dimensional NMR spectroscopy. Bioavailability parameters were predicted in silico , and possible protein targets were predicted by protein-ligand docking.
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