Characterisation of RT-QuIC negative cases from the UK National CJD Research and Surveillance programme

Dominic Ng,Neil Watson, Eugene Ace McDermott,Hatice Kurucu,David Summers,Mary Andrews,Alison Green,Marcelo Barria, Janet McKenzie,Johnny Tam,Colin Smith,Suvankar Pal

Journal of Neurology（2024）

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摘要

Incorporation of the real-time quaking-induced conversion (RT-QuIC) assays for diagnosis of sporadic Creutzfeldt-Jakob disease (CJD) has transformed diagnosis largely related to its extremely high specificity. However, the test has a c.10

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关键词

Creutzfeldt–Jakob disease,Sporadic,Prion,CSF,RT-QuIC,Surveillance

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