Polydopamine-integrated tumor decellularized extracellular matrix hydrogel microparticles for wound healing

The decellularized scaffold materials have demonstrated value for wound healing. The current research focus is exploring more effective decellularized matrices and constructing advanced functional structures to enhance wound repair effectiveness. Here, polydopamine (PDA)-integrated tumor decellularized extracellular matrix (TDECM) and alginate (Alg) composite hydrogel microparticles (Alg@TDECM/PDA) with self-adhesive, nutrition supply, and photothermal performance were fabricated through microfluidic electrospray for the healing of infected wounds. The Alg@TDECM/PDA with PDA integration can adhere to the skin and various substrate surfaces, demonstrating excellent adhesion ability. Besides, owing to the existence of PDA, the hydrogel microparticles exhibit excellent photothermal capability, swiftly eradicating bacteria under near-infrared light irradiation. In addition, the TDECM, obtained from the liver tumor tissue, contained various nutrients that could promote defective tissue repair. Thus, it is demonstrated that the fabricated hydrogel microparticles could significantly accelerate bacterial-infected wound healing by photothermal antibacterial and facilitating angiogenesis at the wound site. These results suggest that such composite hydrogel microparticles containing biocompatible bio-derived materials hold great potential value in clinical applications.