Association of an impaired GH-IGF-I axis with cardiac wasting in patients with advanced cancer

Ann-Kathrin Fröhlich,Jan Porthun,Khawaja M. Talha,Alessia Lena,Sara Hadzibegovic,Ursula Wilkenshoff,Frederike Sonntag, Anja Nikolski, Luisa Valentina Ramer,Tanja Zeller,Ulrich Keller,Lars Bullinger,Stefan D. Anker,Wilhelm Haverkamp,Stephan von Haehling,Wolfram Doehner,Ursula Rauch,Carsten Skurk,John G. F. Cleland,Javed Butler,Andrew J. S. Coats,Ulf Landmesser,Mahir Karakas,Markus S. Anker

Clinical Research in Cardiology（2024）

引用 0|浏览3

暂无评分

摘要

Growth hormone (GH) resistance is characterized by high GH levels but low levels of insulin-like growth factor-I (IGF-I) and growth hormone binding protein (GHBP) and, for patients with chronic disease, is associated with the development of cachexia. We investigated whether GH resistance is associated with changes in left ventricular (LV) mass (cardiac wasting) in patients with cancer. We measured plasma IGF-I, GH, and GHBP in 159 women and 148 men with cancer (83

查看译文

关键词

Left ventricular mass,Growth hormone,Insulin-like growth factor-I,Cardiology,Cancer,Echocardiography,Cachexia

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要