Dynamics of nano-scale assemblies of amphiphilic PEG-PDMS-PEG copolymers
arxiv(2024)
摘要
Micelles and vesicles are promising candidates in targeted drug/gene
delivery, bioreactors, and templates for nanoparticle synthesis. We
investigated the morphology and dynamics of PEG-PDMS-PEG triblock copolymer
nano-scale assemblies regarding the membrane dynamics because the molecular
dynamics of the membrane govern mechanical properties like the stability of a
membrane. We studied the structure by cryogenic transmission electron
microscopy, small-angle neutron scattering, and the dynamics by dynamic light
scattering and neutron spin echo spectroscopy. We changed the length of the
hydrophilic block to obtain micellar and vesicular systems. The vesicle has a
membrane rigidity, κ_η = 16 ± 2 k_B T, the same order of magnitude
as the corresponding liposome value but one order of magnitude higher than
polymeric interfaces in microemulsions. Hence, the height-height fluctuations
of polymers in a polymersome seem much less than those measured for surfactants
at an oil-water interface. Therefore, the polymersome is substantially more
stable. The value is very close to liposomes, indicating a similar stability.
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