Binding Studies of Novel Manganese Complexes to DNA
Russian Journal of Inorganic Chemistry(2024)
摘要
A new Mn(II) complex was designed and synthesized in hydrothermal conditions using phenylmalonic acid and phosphine as raw materials. The effective characterization method was single-crystal X-ray diffraction. Besides, the interaction with FS-DNA (fish sperm DNA) and the DNA binding constants of the complex were determined by UV spectroscopy. The results showed that it was a significant apoptotic effect on cancer cells; therefore, the synthesized Mn(II) complex is important for the treatment of cancer.
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关键词
complex,fluorescence spectra,apoptosis,DNA
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