Antiadhesion Biomaterials in Tendon Repair: Application Status and Future Prospect

The healing process after tendon injury is often accompanied by the formation of peritendinous adhesion, contributing to limb dysfunction and exerting detrimental effects on the individuals, as well as the development of society and economy. With the continuous development of material science, as well as the augmented understanding of tendon healing and the mechanism of peritendinous adhesion formation, materials used for the fabrication of barrier membranes against peritendinous adhesion emerge endlessly. In this article, based on the analysis of the mechanism of adhesion formation, we first review the commonly used natural and synthetic materials, along with their corresponding fabrication strategies, in order to furnish valuable insights for the future optimization and development of antiperitendinous adhesion barrier membranes. This article also discusses the interaction between antiadhesion materials and cells for ameliorating peritendinous adhesion. Impact Statement Peritendinous adhesion is a common complication after tendon injuries, often leading to limb motor dysfunction and posing a significant threat to the physical and mental health of patients. With the development of material science, novel antiperitendinous adhesion barrier membranes have been an effective method to reduce or even prevent peritendinous adhesion. In this article, we provide a comprehensive review and analysis of the materials and fabrication strategies used to create barrier membranes for preventing peritendinous adhesion, and we delve into the mechanisms of adhesion formation. We also explore the interactions between these antiadhesion materials and cells, providing insights into the solution of this clinical problem in the treatment of peritendinous adhesion. By summarizing the current advances in the field, we strongly confirm that biomaterials are a promising strategy for the treatment of peritendinous adhesion.