Glofitamab stimulates immune cell infiltration of CNS tumors and induces clinical responses in secondary CNS lymphoma

James K. Godfrey,Lei Gao,Geoffrey Shouse,Joo Y. Song, Stacy Pak,Brian Lee, Bihong T. Chen,Avyakta Kallam,John H. Baird,Guido Marcucci,Lucy Ghoda, Stephanie Vauleon,Alexey V. Danilov,Alex F. Herrera,Larry W. Kwak,Lihua E. Budde

Blood（2024）

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摘要

Although CD20xCD3 bispecific antibodies are effective against systemic B-cell lymphomas, their efficacy in CNS lymphoma is unknown. Here, we report the CD20xCD3 bispecific, glofitamab, penetrates the blood-brain barrier, stimulates immune-cell infiltration of CNS tumors, and induces responses in CNS lymphoma.

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