Efficient construction of multi-stimuli responsive colloidosomes for intelligent transmembrane transport

The colloidosome, as a kind of Pickering microcapsule, offers a highly functionalizable approach for encapsulation, but current studies mainly focus on shells that lack real-time modulated permeability. Herein, a scalable spray drying method was employed to fabricate temperature/near-infrared (NIR)/magnetic multi-stimuli responsive colloidosomes with adjustable permeability, facilitating intelligent transmembrane transport of molecules. The colloidosomes assembled with SiO2/polydopamine/poly (N-isopropyl acrylamide) nanoparticles can be heated from 25 degrees C to 50 degrees C within 5 min upon NIR exposure. The permeability of shells regulated by temperature and NIR allows for real-time remote control. Yeast cells, as an example, are encapsulated within colloidosomes. The decomposition rate of H2O2 varies with temperature (25-45 degrees C) and NIR intensity (0.5-1 W cm-2), which can attain a more than sixfold increase in the rate constant of pseudo-first-order kinetic model. Furthermore, the strategy was expanded by encapsulating doxorubicin/UiO-66 particles, highlighting its great potential in realms of multi-stimuli responsive colloidosomes applications.