Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique

Carla Mariner-Llicer, Belen Saavedra Cervera,Edson Mambuque,Neide Gomes,Shilzia Munguambe,Luis Villamayor,Irving Cancino-Munoz,Manuela Torres-Puente,Dinis Nguenha,Durval Respeito, Gustavo Tembe,Mariana G. Lopez,Inaki Comas,Alberto L. Garcia-Basteiro

CLINICAL INFECTIOUS DISEASES（2024）

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摘要

Multidrug-resistant(MDR) tuberculosis in Southern Africa is of great concern, exacerbated by the spread of a clone harboring a mutation missed by Xpert Ultra. In Southern Mozambique, the presence of such mutation and rising cases of non-MDR isoniazid resistance highlights the need to ensure accurate detection of antimicrobial-resistance in the country.

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关键词

Mycobacterium tuberculosis,whole-genome sequencing,resistance conferring mutations,Mozambique

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