Dual role of DMSO in the intermolecular oxygenative bifunctionalization of ynamides

A simple HNTf2/DMSO system has been developed for the intermolecular oxgenative bifunctionalization of ynamides to produce various alpha-functionalized amides, where DMSO functions both as the oxygen donor and the solvent. Scope study shows that electron -rich ynamides and nucleophiles such as alcohols, thiols and electronrich arenes are suitable reaction partners in this transformation.