Real-world outcomes of Omnipod DASH system use in people with type 1 diabetes: Evidence from the Association of British Clinical Diabetologists (ABCD) study
DIABETES RESEARCH AND CLINICAL PRACTICE(2024)
摘要
Aims: To evaluate real -world outcomes in people with Type 1 Diabetes (PwT1D) initiated on Omnipod DASH (R) Insulin Management System. Methods: Anonymized clinical data were submitted to a secure web -based tool within the National Health Service network. Hemoglobin A1c (HbA1c), sensor -derived glucometrics, total daily dose of insulin (TDD), and patientreported outcome changes between baseline and follow-up were assessed. Individuals were classified to "new -topump" (switched from multiple daily injections) and "established -on -pump" (switched from a tethered insulin pump) groups. Results: 276 individuals from 11 centers [66.7 % female; 92 % White British; median age 41 years (IQR 20-50); diabetes duration 20 years (IQR 11-31); 49.3 % within "new -to -pump" group] were included. Baseline HbA1c was 8.0 +/- 1.3 % (64 +/- 14 mmol/mol). At follow-up [3 years (IQR 1.5-3.2)], HbA1c reduced by 0.3 % [(3 mmol/ mol); p = 0.002] across the total population, 0.4 % [(5 mmol/mol); p = 0.001] in those "new -to -pump" and remained unchanged in those "established -on -pump". TDD decreased in the "new -to -pump" cohort (baseline:44.9 +/- 21.0units vs follow-up:38.1 +/- 15.4units, p = 0.002). Of those asked, 141/143 (98.6 %) stated Omnipod DASH had a positive impact on quality of life. Conclusions: Omnipod DASH was associated with improvements in HbA1c in PwT1D "new -to -pump" and maintained previous HbA1c levels in those "established -on -pump". User satisfaction in all groups and TDD reduction in those "new -to -pump" were reported.
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关键词
Continuous subcutaneous insulin infusion,Omnipod DASH,Tubeless insulin pump,Type 1 diabetes mellitus,Diabetes technology
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