JMEMS Letters.1pt Infrared-Driven Rapid Quantification of Magnetophoretically Trapped Drug

This work presents a rapid quantification approach for on-chip, trapped magnetic nanoparticle drug conjugate (MD) and tests itsin-vitroefficacy using an integrated piezoelectric/ferromagnetic bilayer structure-based magnetoelectric sensor coupled magnetic microfluidicdevice. The MD trapping is accomplished using triangular-shaped, pat-terned permanent magnet integrated using elastomer-free, pure NdFeBmicro-powder that generates magnetic forces up to 0.2 pN on MDs.This trapped drug is flushed in a local concentration at the outlet wellof the microfluidic device, where the magnetoelectric sensor is placed.The concentration and position of the trapped MD varies with thechange in flow rate from 0.01-0.1 mu l/min. Upon exposure to IR (Infrared)irradiation pulses, the sensor detects 0.33-0.21 nA current for 0-500 mu g/ml concentration due to the pyroelectric effect and exhibits remarkable sensitivity (0.33 nA.ml/mu g) and response time (<2s).[2023-0218]